9A1P9 (Ionizable): 9A1P9 is a chemical compound with ionizable properties, often used in various research and industrial applications. Its ionizable nature makes it suitable for use in pharmaceuticals, materials science, and chemical synthesis.

Chemical Specifications

• CAS Number: 2760467-57-8
• Molecular Formula: C₁₀H₁₂N₂O₃
• Molecular Weight: Approximately 220.22 g/mol

Physical and Chemical Properties

• Appearance: White powder
• Solubility: Soluble in water, ethanol
• Melting Point: 150°C
• Boiling Point: 300°C
• Density: 1.2 g/cm³
• pH: 7 (neutral)
• Stability: Stable under normal conditions
• Reactivity: Non-reactive with common chemicals

        H   H   H
        |   |   |
    H---C---C---C---H
    |   |   |   |   |
H---N---C---C---N---H
    |   |   |   |   |
    H---C---C---C---H
        |   |   |
        H   H   H
        

ALC-0315 (Ionizable Lipid): ALC-0315 is a lipid compound with ionizable properties, commonly used in various research and industrial applications.

Chemical Specifications

• CAS Number: 2036272-55-4
• Molecular Formula: C₄₈H₉₅NO₅
• Molecular Weight: Approximately 766.29 g/mol

Physical and Chemical Properties

• Purity: >95%
• Categories: Lipids
• Filter: Ionizable/Cationic Lipids
• Storage: 4°C or below
• Shipping Temp: Gel Ice
• Hygroscopic: Yes
• Light Sensitive: No

Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for research use only and not for human use. Additional information can be found here.

Chemical Specifications

• CAS Number: 1432494-65-9
• Molecular Formula: C₆₀H₁₂₀N₄O₆
• Molecular Weight: Approximately 993.64 g/mol
• Purity: 0.95

Physical and Chemical Properties

• Solubility: Chloroform, methanol, ethanol
• Storage: Store dry at 4°C or below. Stock solutions should be stored at -20°C.
• Shipping Temperature: Gel Ice

Background

Cationic lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. cKK-E12 has been used to deliver siRNA in mice, rats, and primates (ED50 = 0.002, 0.01, & 0.3 mg/kg respectively). It shows low toxicity and is selective for liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is for research use only and not for human use.

References

1. Dong et al. (2014) Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. PNAS Mar 18;111(11):3955-60
2. M.A. Oberli, A.M.Reichmuth, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett, 17, 1326 (2017).
3. Miao, L., Lin, J., Huang, Y. et al. Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver. Nat Commun 11, 2424 (2020).

Ionizable lipids, in combination with other lipids, form lipid nanoparticles essential for delivering RNA-based therapeutics. cKK-E12 has demonstrated effective delivery of siRNA in mice, rats, and primates, with respective ED50 values of 0.002, 0.01, & 0.3 mg/kg. It exhibits low toxicity and preferential targeting of liver parenchymal cells over liver, heart, lung, and kidney endothelial cells. This product is exclusively for research purposes and not intended for human use

Chemical Specifications

• CAS Number: 1432494-65-9
• Molecular Formula: C₆₀H₁₂₀N₄O₆
• Molecular Weight: Approximately 993.64 g/mol
• Purity: 0.95

Physical and Chemical Properties

• Solubility: Chloroform, methanol, ethanol
• Storage: Store dry at 4°C or below. Stock solutions should be stored at -20°C.
• Shipping Temperature: Gel Ice

Background

Cationic lipids, when combined with other lipids, form lipid nanoparticles for delivering RNA-based therapeutics. cKK-E12 has been successfully utilized to deliver siRNA in mice, rats,

DLin-DMA: DLin-DMA is an ionizable lipid used in combination with other lipids to formulate lipid nanoparticles (LNPs) for the delivery of nucleic acids such as siRNA and mRNA. Studies have demonstrated the efficacy of DLin-DMA-based LNPs in delivering nucleic acids to target cells both in vitro and in vivo.

Chemical Specifications

• Formal Name: N,N-dimethyl-2,3-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]-1-propanamine
• CAS Number: 871258-12-7
• Synonyms: 1,2-Dilinoleyloxy-N,N-dimethyl-3-aminopropane
• Molecular Formula: C41H77NO2
• Purity: ≥95%
• Formulation: A solution in ethanol (Request formulation change)
• Solubility:
  • DMF: 2 mg/ml
  • DMSO: insol
  • Ethanol: 10 mg/ml
  • PBS (pH 7.2): insol
• SMILES: CCCCC/C=C\C/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\C/C=C\CCCCC
• InChi Code: InChI=1S/C41H77NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-

DLin-MC3-DMA is an ionizable lipid employed in conjunction with other lipids to encapsulate RNA and DNA into lipid nanoparticles (LNPs). Studies have demonstrated that LNPs formulated with DLin-MC3-DMA can effectively deliver siRNA, resulting in a reduction of Factor VII levels in murine models. Furthermore, the delivery of BCR-ABL siRNA using DLin-MC3-DMA LNPs has shown promising outcomes in reducing the leukemic burden in a mouse model of chronic myeloid leukemia (CML). Additionally, research is underway to develop a formulation based on DLin-MC3-DMA for the treatment of Hereditary Transthyretin-Mediated (hATTR) Amyloidosis in clinical settings

DLin-MC3-DMA Information

• Molecular Formula: C43H79NO2
• Molecular Weight (MW): 642.11
• CAS Number: 1224606-06-7
• Alternative Names: (6Z,9Z,28Z,31Z)-heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate
• Solubility: DLin-MC3-DMA is soluble in methanol, ethanol, chloroform, and DMSO.
• Storage and Handling: It should be stored dry at -20 °C. Stock solutions must be kept frozen at -20 °C or below.

Background

DLin-MC3-DMA is an ionizable lipid employed in conjunction with other lipids to encapsulate RNA and DNA into lipid nanoparticles (LNPs). Studies have demonstrated that LNPs formulated with DLin-MC3-DMA can effectively deliver siRNA, resulting in a reduction of Factor VII levels in murine models. Furthermore, the delivery of BCR-ABL siRNA using DLin-MC3-DMA LNPs has shown promising outcomes in reducing the leukemic burden in a mouse model of chronic myeloid leukemia (CML). Additionally, research is underway to develop a formulation based on DLin-MC3-DMA for the treatment of Hereditary Transthyretin-Mediated (hATTR) Amyloidosis in clinical settings

DODMA: DODMA, or 1,2-dioleyloxy-3-dimethylaminopropane, is a cationic lipid commonly used as a non-viral carrier for gene therapy. It is utilized in the preparation of cationic liposomes or lipid nanoparticles (LNP) requiring a neutral or low zeta potential. DODMA exhibits high efficacy in encapsulating nucleic acids, attributed to its capability to transiently reduce pH.

Chemical Specifications

Physical Specifications

Lipid 319 is an ionizable and biodegradable lipid. Lipid 319 nanoparticles have better delivery efficacy and biodegradability than DLin-MC3-DMA in the delivery of mRNA in vivo. MC3 is the key delivery nanoparticle component of the first siRNA drug Onpattro.

Chemical Specifications

• CAS Number: 1351586-50-9
• Molecular Formula: C₄₁H₇₅NO₆
• Molecular Weight (g/mol): 678.05

Physical and Chemical Properties

• Solubility: Methanol, ethanol, DMSO, and dimethyl formamide
• Storage: Stable for at least one year when stored as a solid at -20°C
• Storage Temperature: -20°C or below
• Shipping Temp: Ambient Temperature

Alternate Names

9-[4-(dimethylamino)-1-oxobutoxy]-heptadecanedioic acid, 1,17-di-(2Z)-2-nonen-1-yl ester
Di((Z)-Non-2-en-1-yl)9-((4-(dimethylamino)butanoyl)oxy)heptadecanedioate

Ionizable lipids, when combined with other lipids, make up the lipid nanoparticles (LNPs) used to deliver RNA-based therapeutics. LNPs incorporating Lipid 5 (from Sabnis et al.) have shown potent delivery of mRNA in primates, although they are rapidly cleared from the body, resulting in low toxicity. Lipid 5 is particularly effective for intravenous delivery to the liver, whereas the closely related SM-102 is optimized for intramuscular administration. This product is intended for research purposes only and is not for human use.

Chemical Specifications

• CAS Number: 2089251-33-0
• Molecular Formula: C₄₄H₈₇NO₅
• Molecular Weight: 710.18 g/mol

Physical and Chemical Properties

• Solubility: Chloroform, methanol, ethanol
• Alternate Name: Heptadecan-9-yl 8-((2-hydroxyethyl)(8-(nonyloxy)-8-oxooctyl)amino)octanoate
• Storage and Handling: Store dry at -20°C or below. Stock solutions should be stored at -20°C.

SM-102 is a cationic lipid used in lipid nanoparticles (LNPs). LNP compositions have proven effective as transport vehicles into cells and/or intracellular compartments for biologically active substances such as small molecule drugs, proteins, and nucleic acids.

Chemical Specifications

• Molecular Formula: C₄₄H₈₇NO₅
• Molecular Weight (g/mol): 710.18
• CAS Number: 2089251-47-6
• Alternative Names: Heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate
• Solubility: ~5mg/mL chloroform

Storage & Handling

• Storage: Store dry at -20°C
• Stock Solution Storage: Store frozen (-20°C or below)

DOTMA is a cationic lipid used in lipid nanoparticles (LNPs). LNP compositions have proven effective as transport vehicles into cells and/or intracellular compartments for biologically active substances such as small molecule drugs, proteins, and nucleic acids. This is a reagent grade product, for research use only.

SMILES: OCCN(CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O)CCCCCC(OCCCCCCCCCCC)=O

InChi Code: InChI=1S/C44H87NO5/c1-4-7-10-13-16-17-18-24-32-41-49-43(47)35-29-25-31-38-45(39-40-46)37-30-23-19-22-28-36-44(48)50-42(33-26-20-14-11-8-5-2)34-27-21-15-12-9-6-3/h42,46H,4-41H2,1-3H3

InChi Key: BGNVBNJYBVCBJH-UHFFFAOYSA-N

Shipping & Storage Information: Dotma is stable for at least one year when stored as a solid, protected from moisture, and light at -20°C. Solutions of Dotma should be stored at -20°C between uses.

DOTAP forms stable cationic liposomes in solution and can be used in the cell transfection of DNA, RNA, oligonucleotides, anionic proteins, and small peptides.

Physical and Chemical Properties

DODMA: DODMA, or 1,2-dioleyloxy-3-dimethylaminopropane, is a cationic lipid commonly used as a non-viral carrier for gene therapy. It is utilized in the preparation of cationic liposomes or lipid nanoparticles (LNP) requiring a neutral or low zeta potential. DODMA exhibits high efficacy in encapsulating nucleic acids, attributed to its capability to transiently reduce pH.

Chemical Specifications

Physical Specifications

Cholesterol: Cholesterol is a lipid molecule that is essential for the normal functioning of the body. It is a sterol, a type of lipid molecule, and is found in the cell membranes of all animal tissues. Cholesterol is important for maintaining membrane fluidity and is a precursor for the synthesis of steroid hormones, bile acids, and vitamin D.

Chemical Specifications

• CAS Number: 57-88-5
• Molecular Formula: C₂₇H₄₆O
• Molecular Weight: Approximately 386.65 g/mol

Physical and Chemical Properties

• Appearance: White crystalline solid
• Solubility: Insoluble in water, soluble in organic solvents
• Melting Point: Approximately 145-147°C
• Boiling Point: Not applicable (decomposes)
• Density: ~1.06 g/cm³
• pH: Neutral
• Stability: Stable under normal conditions
• Reactivity: May oxidize in the presence of air or light

                 H
                 |
                 C=C
                /   \
            H-C     C-H
            |       |
        H-C-C     C-C-H
        |   |     |   |
        H   C     C   H
            |     |
            C     C
            |     |
            C     C
           / \   / \
          H   C=C   C-H
             /     \
            H       H